Yuou TENG

admin-ajax-5Associate Prof. Yuou Teng

Contact: tyo201485@tust.edu.cn

Her research fields involve in biological activity evaluation and mechanism study of small molecule compounds in medicinal chemistry and chemical biology fields. She has over 20 publications, including Chemistry, Pure Appl. Chem., Eur J Cell Biol., Eur J Med Chem., Biochem. Biophys. Res. Commun.and Bioorg Med Chem Lett. etc. Prof. Teng is principal investigator of National Natural Science Fund Project

Representative Publications

  1. Qian Zhang#, Yuou Teng#, Yuan Yuan, Tingting Ruan, Qi Wang, Xing Gao, Yao Zhou, Kailin Han, Peng Yu*, Kui Lu**. Synthesis and cytotoxic studies of novel 5-phenylisatin derivatives and their anti-migration and anti-angiogenic evaluation. European Journal of Medicinal Chemistry, 2018, 156 :800-814.
  2. Cen Xiang#, Yuou Teng#, Chaoran Yao ,Xuehui Li, Menglin Cao, Xuzhe Li, Guojun Pan, Kui Lu, Hervé Galons*, Peng Yu*. Antioxidant properties of flavonoid derivatives and their hepatoprotective effects on CCl4 induced acute liver injury in mice. RSC Advances, 2018, 8: 15366 – 15371.
  3. Guojun Pan, Xuehui Li, Long Zhao, Meng Wu, Chao Su, Xuzhe Li, Yongmin Zhang, Peng Yu, Yuou Teng*, Kui Lu*.Synthesis and anti-oxidant activity evaluation of (±)-Anastatins A, B and their analogs. European Journal of Medicinal Chemistry, 2017, 138 :577-589.
  4. Yuou Teng, Xuzhe Li, Ke Yang, Xuehui Li, Zijun Zhang, Luyao Wang, Zhijie Deng, BinbinSong, Zhihong Yan, Yongmin Zhang, Kui Lu∗, Peng Yu∗∗. Synthesis and antioxidant evaluation of desmethylxanthohumol analogsandtheir dimers, European Journal of Medicinal Chemistry, 2017, 125 :335-345.
  5. Yuou Teng, Lixin Wang, Huan Liu, Yuan Yuan, Qian Zhang, Meng Wu, Luyao Wang, Haomeng Wang, Zhen Liu*, Peng Yu*. 3’-Geranyl-mono-substituted chalcone Xanthoangelovl induces apoptosis in human leukemia K562 cells via activation of mitochondrial pathway. Chemico-Biological Interactions.2017, 261:103-107.
  6. Yuou Teng, Hongye Zhao, Jing Wang, Huan Liu, Mele Gao, Yao Zhou, Kailin Han, Zhenchuan Fan, Yongmin Zhang, Hua Sun*, Peng Yu*. Synthesis and Anti-cancer Activity Evaluation of 5-(2-Carboxyethenyl)-isatin Derivatives, European Journal of Medicinal Chemistry, 2016, 112(1):145-156.
  7. Yao Zhou, Hongye Zhao, Du Jiang, Luyao Wang, Cen Xiang, Shaopeng Wen, Zhenchuan Fan, Yongmin Zhang, Na Guo, Yuou Teng*, Peng Yu*, Low toxic and high soluble camptothecin derivative e 2–47 effectively induces apoptosisof tumor cells in vitro, Biochemical and Biophysical Research Communications,2016,472:477-481.
  8. Haomeng Wang, Li Zhang, Jiang liu, Zhaoliang Yang, Hongye Zhao, Yao Yang, Di Shen, Kui Lu, Zhenchuan Fan, Qingwei Yao, Yongmin Zhang, Yuou Teng*, Peng Yu*. Synthesis and Anti-cancer Activity Evaluation of Novel Prenylated and Geranylated Chalcone Natural Products and Their Analogs. European Journal of Medicinal Chemistry,2015,92:439-448.
  9. Yao Zhou, Hongye Zhao, Kailin Han, Yao Yang, Binbin Song, Qiannan Guo, Zhenchuan Fan, Yongmin Zhang, Yuou Teng*, Peng Yu*. 5-(2-Carboxyethenyl) isatin derivative induces G2/M cell cycle arrest and apoptosis in human leukemia K562 cells. Biochemical and Biophysical Research Communications. 2014, 450:1650–1655.
  10. Kailin Han, Yao Zhou, Fengxi Liu, Qiannan Guo, Pengfei Wang, Yao Yang, Binbin Song, Wei Liu, Qingwei Yao, Yuou Teng*, Peng Yu*. Design, Synthesis and In Vitro Cytotoxicity Evaluation of 5-(2-Carboxyethenyl)isatin Derivatives as Anticancer Agents. Bioorg Med Chem Lett. 2014,24(2):591–594.
  11. Yuou Teng, Katsuya Iuchi, Eriko Iwasa, Shinya Fujishiro, Yoshitaka Hamashima, Kosuke Dodo, and Mikiko Sodeoka*. Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase-8/caspase-3 activation. Bioorg Med Chem Lett. 2010,20(17): 5085-5088.
  12. Yuou Teng, Yusuke Takahashi, Makiko Yamada, Tetsuya Kurosu, Takatoshi Koyama, Osamu Miura, Tohru Miki*. IRF4 negatively regulates proliferation of germinal centre B cell-derived Burkitt’s lymphoma cell lines and induces differentiation toward plasma cells. European Journal of Cell Biology. 2007, 86(10): 581-589.