Dong WANG

Contact: wangdong@tust.edu.cn

Personal website in Chinese at TUST

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Prof. Wang got his Ph.D. from Louisiana State University (USA) in 2011 on the synthesis of bicyclo[n.3.1]alkanones to develop novel antidepressant agents. After his PhD, he joined the Longwood Biopharmaceutical company working on the design and synthesis of inhibitors of hepatitis C virus NS3 protease. He joined TUST as an associate Professor in 2015.

Prof. Wang is principal investigator of Tianjin Natural Science Foundation, Tianjin Municipal Science and Technology Commission Project.

CURRENT  RESEARCH  INTEREST: Funtionalization of N-heteroaromatics and application in medicinal chemistry

Research in our group is focused primarily upon the development of new strategies and methodologies for the synthesis of N-heteroaromatics. We have successfully established mild and efficient methods for the halogenation and hydroxylation of N-heteroaromatics. The efficient and fast access to azacoumarins and azachromones (including azaflavones) is under investigation currently. Finally, those developed methods will be applied to the preparation of known medicines, seeking improved synthetic strategies compared to those known synthesis.

PUBLICATIONS

21. Dong Wang,* Yuanyang Jiang, Linru Dong, Gaoyu Li, Baoying Sun, Laurent Désaubry and Peng Yu. A one-pot selective saturation and functionalization of heteroaromatics leading to dihydropyridines and dihydroquinolines. J. Org. Chem. 85: in press (2020) doi: 10.1021/acs.joc.0c00314.

20. Wang D., Redouane Tabti, Sabria Elderwish, Hussein Abou-Hamdan, Amel Djehal, Peng Yu, Hajime Yurugi, Krishnaraj Rajalingam, Canan G. Nebigil and Laurent Désaubry* Prohibitin ligands: a growing armamentarium to tackle cancers, osteoporosis, inflammatory, cardiac and neurological diseases. Wang D., Tabti R.,  Elderwish S., Abou-Hamdan H., Djehal A., Yu P., Yurugi H., Rajalingam R., Nebigil CG., Désaubry L. Cell. Mol. Life Sci. 77: in press (2020). DOI: 10.1007/s00018-020-03475-1

19. Dong Wang,* Xinyue Ma, Linru Dong, Hairong Feng, Peng Yu and Laurent Désaubry*. Stereoselective four-component synthesis of functionalized 2,3- dihydro-4-nitropyrroles. Frontiers in Chemistry, 2019, 7:810, doi: 10.3389/fchem.2019.00810.

18. Dong Wang,* Zhentao Wang, Zhenlin Liu, Mindong Huang, Jianyong Hu, and Peng Yu*. Strategic C-C Bond-Forming Dearomatization of Pyridines and Quinolines. Organic Letters, 2019, 21(12), 4459-4463. 

17. Dong Wang,* Zhenlin Liu, Zhentao Wang, Xinyue Ma, and Peng Yu.* Metal- and base-free regioselective thiolation of the methyl C(sp3)–H bond in 2-picoline N-oxides. Green Chemistry, 2019, 21 (1), 157-163.

Graphical abstract: Metal- and base-free regioselective thiolation of the methyl C(sp3)–H bond in 2-picoline N-oxides16. Amel Djehal, Mohammad Krayem, Ahmad Najem, Hassan Hammoud, Thierry Cresteil, Cannon Nebigil, Dong Wang, Peng Yu, Embak Bentouhami, Ghanem Ghanem, Laurent Désaubry*. Targeting prohibitin with small molecules to promote melanogenesis and apoptosis in melanoma cells.  European Journal of Medicinal Chemistry, 2018, 155, 880-888.

15. Dong Wang, Linna Li, Hairong Feng, Hua Sun, Fabrice Almeida-Veloso, Marine Charavin, Peng Yu, Laurent Désaubry*. Catalyst-free three-component synthesis of highly functionalized 2,3-dihydropyrroles. Green Chem. 20: 2775-2780 (2018).

14. Dong Wang,* Jianyong Hu, Junjie Zhao, Meng Shen, Yuxi Wang, and Peng Yu*. Transition-metal-free access to 7-azaindoles. Tetrahedron, 2018, 74 (30), 4100-4110.

13. Dong Wang,* Meng Shen, Yuxi Wang, Jianyong Hu, Junjie Zhao, and Peng Yu*. Access to Furo[2,3-b]pyridines by Transition-Metal-Free Intramolecular Cyclization of C3-substituted Pyridine N-oxides. Asian Journal of Organic Chemistry, 2018, 7(5), 879-882.

12. Dong Wang,* Hairong Feng, Linna Li, Zhenlin Liu, Zhongli Yang, and Peng Yu*. Access to 8-Azachromones via Activation of C-H in N-Oxides. Journal of Organic Chemistry, 2017, 82(20), 11275-11287.

11Dong Wang,* Hairong Feng, Linna Li, Zhenlin Liu, Zhongli Yang, and Peng Yu*. Strategic Approach to 8-Azacoumarins. Organic Letters, 2017, 19(5), 984-987.

10. Dong Wang,* Junjie Zhao, Yuxi Wang, Jianyong Hu, Linna Li, Longfei Miao, Hairong Feng, Laurent Désaubry, and Peng Yu*. A General and Efficient Synthesis of 2-Pyridones, 2-Quinolinones, and 1-Isoquinolinones from Azine N-Oxides. Asian Journal of Organic Chemistry, 2016, 5(12), 1442-1446.

9. Dong Wang, Yuxi Wang, Junjie Zhao, Linna Li, Longfei Miao, Dong Wang, Hua Sun and Peng Yu. A Highly Practical and Convenient Halogenation of Fused Heterocyclic N-oxides. Tetrahedron, 2016, 72(38), 5762-5768.

8. Hua Sun, Yazhou Zhang, Weina Ding, Xue Zhao, Xiaotong Song, Dong Wang, Yashan Li, Kailin Han, Yang Yang, Ying Ma, Runling Wang, Dong Wang*, Peng Yu**. Inhibitory activity evaluation and mechanistic studies of tetracyclic oxindole derivatives as α-glucosidase inhibitors. Eur. J. of Med. Chem. 2016, 123(10), 365-378.

7. Dong Wang, Longfei Miao, Lixia Feng, Qingwei Yao, Gnel Mkrtchyan, William E. Crowe, Evgueni E. Nesterov, Yuekui Wang, Xiaoting Zhang and Peng Yu. Mechanism and origin of stereoselectivity in Robinson annulations leading to bicyclo[3.3.1]nonanes: a rare Curtin-Hammet scenario. J. Phys. Org.Chem. 2017, 30: e3595.

6. Dong Wang,* William E. Crowe. A facile approach to tricyclo[6.4.0.04,9]-dodecane framework. Chinese Chemical Letters, 2015, 26(2), 238-242.

5. Dong Wang,* Hailing Jia, Wuchang Wang and Zhe Wang. A practical and mild chlorination of fused heterocyclic N-oxides. Tetrahedron Letters, 2014, 55(51), 7130-7132.

4. Dong Wang and William E. Crowe. One-Carbon Bridge Stereocontrol in Robinson Annulations Leading to Bicyclo[3.3.1]nonanes. Org. Lett. 2010, 12(6), 1232-1235.

3. Dong Wang, William E. Crowe, Robert M. Strongin and Martha Sibrian-Vazquez. Exploring the pH dependence of viologen reduction by α-carbon radicals derived from Hcy and Cys. Chemical Communications, 2009, 14, 1876-1878.

2. Rong Zheng, Changjin Zhu, Yi Liu and Dong Wang. Synthesis of a pair of derivatives of N-methylpyrrole polyamide. Chinese Chemical Letters, 2006, 4(17), 434-436.

1. Dong Wang, Jingmiao Pan, Zengshan Guo, Rong Zheng and Changjin Zhu*. Synthesis and inhibitory activity studies of 1’-  position substituted fidarestat derivatives. Chemical Journal on Internet, 2006, 8(3), 083016pc.